DNA Protective, Aldose Reductase Inhibitory and Anti-cataract Activities of Ferulic Acid

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Authors

  • Nagaraju Bandaru
     1School of Pharmaceutical Sciences (SOPS), Sandip University, Nasik - 422213, Maharashtra, India ,IN
  • Veera Mani Deepika Pedapati
     3Department of Pharmacy Practice, Aditya Pharmacy College, Surampalem, Kakinada – 533437, Andhra Pradesh ,IN
  • Matta Sarika
     Department of Pharmacy Practice, Aditya Pharmacy College, Surampalem, Kakinada – 533437, Andhra Pradesh ,IN
  • Suggu Vangmai Swaroopa
     Department of Pharmacy Practice, Aditya Pharmacy College, Surampalem, Kakinada – 533437, Andhra Pradesh ,IN
  • M. Aparna
     College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddesweram – 522302, Andhra Pradesh ,IN
  • Md. Said Ibrahim
     College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddesweram – 522302, Andhra Pradesh ,IN
  • Makarand Suresh Gambhire
     School of Pharmaceutical Sciences (SOPS), Sandip University, Nasik - 422213, Maharashtra ,IN
  • Ramu Samineni
     School of Pharmaceutical Sciences (SOPS), Sandip University, Nasik - 422213, Maharashtra ,IN
  • M. Narender
     College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddesweram – 522302, Andhra Pradesh ,IN
  • Prashik B. Dudhe
     School of Pharmaceutical Sciences (SOPS), Sandip University, Nasik - 422213, Maharashtra ,IN

Keywords:

Antioxidants, DNA, Docking, Diabetes, Ferulic Acid, Glucose Concentrations

Abstract

The current study assessed Ferulic acid’s DNA protective, aldose reductase inhibitory and anti- cataract activities. Different concentrations of ferulic acid are examined for DNA protection and incubated with aldose reductase isolated from a goat lens. Ferulic acid demonstrates a strong inhibitory effect against aldose reductase enzyme with IC50 value of 1.43 g/ mL and shows potent DNA protective action at the dose of 100 ug/mL against Fenton’s reagent induced DNA damage. Ferulic acid also reduces the formation of opacification in goat lens that inhibits the development of cataract and increases antioxidants levels significantly in lenses. This indicated that Ferulic acid inhibits the oxidative stress induced cataract. Based on the findings, Ferulic acid may be an effective option for the treatment of high glucose-induced cataract.

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Published

2024-08-23

How to Cite

Bandaru, N., Pedapati, V. M. D., Sarika, M., Swaroopa, S. V., Aparna, M., Ibrahim, M. S., Gambhire, M. S., Samineni, R., Narender, M., & Dudhe, P. B. (2024). DNA Protective, Aldose Reductase Inhibitory and Anti-cataract Activities of Ferulic Acid. Toxicology International. Retrieved from http://mail.informaticsjournals.com/index.php/toxi/article/view/43004

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Online First

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Copyright (c) 2024 Nagaraju Bandaru, Veera Mani Deepika Pedapati, Matta Sarika, Suggu Vangmai Swaroopa, M. Aparna, Md. Said Ibrahim, Makarand Suresh Gambhire, Ramu Samineni, M. Narender, Prashik B. Dudhe

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Received 2024-03-22
Accepted 2024-06-21
Published 2024-08-23

 

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