Ameliorative Effect of SR48692 on the Testicular and Epididymal Impairments of High-Fat Diet- Induced Swiss Albino Mice
Authors
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Department of Zoology, University of Allahabad, Allahabad – 211002, Uttar Pradesh ,IN
Pradeep Verma -
Department of Zoology, University of Allahabad, Allahabad – 211002, Uttar Pradesh ,INHimanshu Pal
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Department of Zoology, University of Allahabad, Allahabad – 211002, Uttar Pradesh ,INBanalata Mohanty
DOI:
https://doi.org/10.18311/ti/2024/v31i3/42110Keywords:
High-Fat Diet, Histopathology, Neurotensin, Reproduction, SR48692Abstract
This study investigated the role of Neurotensin (NT) receptor-1 antagonist SR48692 on High-Fat Diet (HFD)-induced considerable morphological alterations in the testis and epididymis in mice. Excessive intake of fat and a sedentary lifestyle are major causes of metabolic comorbidities in the current obesogenic environment. Consumption of HFD induces NT release in the gut, which promotes lipid absorption. Elevated NT is associated with metabolic alterations and imbalanced energy status which could be responsible for a negative impact on reproductive outcomes. Male mice (n = 24) were randomly assigned, based on diet into Control Diet (CD) and HFD for 4 weeks; they were further divided into 2 subgroups and administered saline and SR48692 (100 μg/kg b.w.) intraperitoneally for the next 4 weeks. The present findings revealed that HFD-induced obesity caused significant alterations in circulating lipid and reproductive hormone profiles leading to deterioration of testicular and epididymal histoarchitechture. However, the co-treatment of SR48692 with HFD has significantly restored the HFD-induced detrimental effect on lipid and reproductive hormone profiles, justified by the improvements in histoarchitechture of the testis and epididymis. However, only SR48692 administered group showed adverse effects on the studied parameters. The results reported herein showed that SR48692 have the efficacy to actively overcome the HFD-induced detrimental effects. Therefore, SR48692 might be considered for the therapeutic role in HFDinduced reproductive impairments.
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Copyright (c) 2024 Pradeep Verma, Himanshu Pal, Banalata Mohanty
This work is licensed under a Creative Commons Attribution 4.0 International License.
Accepted 2024-05-28
Published 2024-07-24
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