Effect of Cymbopogon schoenanthus L. Spreng Extract on Gentamicin-Induced Renal Toxicity in Rats

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Authors

  • Farah Ramdane
     Faculty of Nature Sciences and Life, El Oued University. PO Box 789, 39000 ,DZ
  • Mounira Kadri
     Biology, Environment and Health Laboratory, El Oued University, PO Box 789, 39000 ,DZ
  • Nour El Houda Mekhadmi
     Department of Biology, Laboratory of Biodiversity and Applications of Biotechnology in the Agriculture Field, University of Echahid Hama Lakhdar, El-Oued ,DZ
  • Asma Atousi
     Faculty of Nature Sciences and Life, El Oued University. PO Box 789, 39000 ,DZ
  • Ouarda Tliba
     ,DZ
  • Mahfoud Hadj Mahammed
     Department of Biology, Laboratory of Biodiversity and Applications of Biotechnology in the Agriculture Field, University of Echahid Hama Lakhdar, El-Oued ,DZ

DOI:

https://doi.org/10.18311/ti/2024/v31i3/35368

Keywords:

Cymbopogon schoenanthus, Gentamicin, Nephroprotective Activity, Poaceae, Polyphenols

Abstract

This study’s objective is to assess phytochemicals content and the protective effect of Cymbopogon schoenanthus hydroethanolic extract on gentamicin-induced renal toxicity in rats. Phytoconstituents were determined by using colorimetric tests. Three methods were used for the evaluation of antioxidant activity. The experiment used gentamicin in six different groups of albino rats. The biochemical analysis of current results displayed a significant reduction in blood urea and creatinine in groups intoxicated with gentamicin and administered two doses of the extract. While the concentration of total proteins and albumins has been increased. In addition, this plant decreased oxidative stress which was translated into a decrease in malondialdehyde content, and increased levels of antioxidant parameters, consequently an improvement in kidney functions. This study revealed a higher content of phenolic compounds, greater antioxidant activity and nephroprotective qualities of Cymbopogon shoenanthus extract for the first time.

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Author Biography

Ouarda Tliba

 

1 Faculty of Nature sciences and Life, El Oued University. PO Box 789. 39000 . Algeria

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Published

2024-07-10

How to Cite

Ramdane, F., Kadri, M., Mekhadmi, N. E. H., Atousi, A., Tliba, O., & Mahammed, M. H. (2024). Effect of <i>Cymbopogon schoenanthus</i> L. Spreng Extract on Gentamicin-Induced Renal Toxicity in Rats. Toxicology International, 31(3), 391–398. https://doi.org/10.18311/ti/2024/v31i3/35368

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Volume 31, Issue 3, July-September 2024

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Articles

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Copyright (c) 2024 Farah Ramdane, Mounira Kadri, Nour El Houda Mekhadmi, Asma Atousi, Ouarda Tliba, Mahfoud Hadj Mahammed

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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Europe PMC
Received 2023-10-16
Accepted 2024-04-14
Published 2024-07-10

 

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