Development and Optimisation of Olive Oil-infused Emulgel from Andrographis Extract Using Quality by Design (QbD) Methodology

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Authors

  • N. V. L. Sirisha Mulukuri
     Nitte College of Pharmaceutical Sciences, Govindapura, Gollahalli, Bangalore - 560064, Karnataka ,IN
  • Kusum Devi
     Nitte College of Pharmaceutical Sciences, Govindapura, Gollahalli, Bangalore - 560064, Karnataka, ,IN
  • N. V. Satheesh Madhav
     Vital Therapeutics and Formulations Pvt. Ltd., Abhinav Colony, Padmarao Nagar, Hyderabad - 500025, Telangana ,IN
  • T. Prabhakar
     Karnataka College of Pharmacy, Bangalore - 50064, Karnataka ,IN
  • Ranjitha
     Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to be University), Mangalore - 575018, Karnataka ,IN
  • Pankaj Kumar
     Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to be University), Mangalore - 575018, Karnataka ,IN

DOI:

https://doi.org/10.18311/jnr/2024/36591

Keywords:

Andrographolide, Characterisation, Emulgel, QbD, Responses

Abstract

Background: Andrographolide, the primary active constituent in Andrographis extract, exhibits poor aqueous solubility, necessitating a novel formulation strategy for effective dermal delivery. Aim: To formulate and optimise olive oil-infused emulgel from Andrographis extract. Methods: Various emulgel formulations were prepared using different combinations of oil and Carbopol 940. The formulations were assessed for visual inspection, pH, spreading ability, extrudability, viscosity, drug content, and in vitro drug release. The optimal formulation (AEE 6) was identified using design expert software based on the evaluated parameters. Results: The emulgel formulations demonstrated varied properties based on the combinations of oil and Carbopol 940 used. The optimized formulation (AEE 6) showed favourable stability under accelerated conditions, maintaining stability across all assessed physicochemical parameters. Conclusion: The emulgel formulation approach successfully addressed the poor aqueous solubility of andrographolide, enhancing its permeation for dermal delivery. The selected formulation (AEE 6) demonstrated optimal characteristics and stability, making it a promising candidate for effective dermal delivery of Andrographis extract.

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Published

2024-08-31

How to Cite

Mulukuri, N. V. L. S., Devi, K., Madhav, N. V. S., Prabhakar, T., Ranjitha, & Kumar, P. (2024). Development and Optimisation of Olive Oil-infused Emulgel from <i>Andrographis</i> Extract Using Quality by Design (QbD) Methodology. Journal of Natural Remedies, 24(8), 1731–1737. https://doi.org/10.18311/jnr/2024/36591

Issue

Volume 24, Issue 8, August 2024

Section

Research Articles

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Copyright (c) 2024 N V L SIRISHA MULUKURI, Pankaj Kumar, prabhakar T, sateesh Madav, Kusum devi (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Europe PMC
Received 2024-02-16
Accepted 2024-07-09
Published 2024-08-31

 

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